Article
The APC E1317Q variant in adenomatous polyps and colorectal cancers.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Oct 2003
Hahnloser D, Petersen G M, Rabe K, Snow K, Lindor N M, Boardman L, Koch B, Doescher D, Wang L, Steenblock K, Thibodeau S N
Abstract excerpt
Genetic susceptibility may play a role in many colorectal cancers (CRCs). Known syndromes such as familial adenomatous polyposis and hereditary nonpolyposis CRC account for <5% of CRCs. The germ-line missense variant of the APC gene, E1317Q, has been proposed to confer a risk for colonic adenomatous polyps (adenomas), but not for CRCs in the general population. These findings are contradictory and controversial....
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