Article
Identification of the haematopoietic stem cell niche and control of the niche size.
Nature - 23 Oct 2003
Zhang Jiwang, Niu Chao, Ye Ling, Huang Haiyang, He Xi, Tong Wei-Gang, Ross Jason, Haug Jeff, Johnson Teri, Feng Jian Q, Harris Stephen, Wiedemann Leanne M, Mishina Yuji, Li Linheng
Abstract excerpt
Haematopoietic stem cells (HSCs) are a subset of bone marrow cells that are capable of self-renewal and of forming all types of blood cells (multi-potential). However, the HSC 'niche'--the in vivo regulatory microenvironment where HSCs reside--and the mechanisms involved in controlling the number of adult HSCs remain largely unknown. The bone morphogenetic protein (BMP) signal has an essential role in inducing...
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