Lung Epithelial Cells and Extracellular Matrix Components Induce Expression of Pneumocystis carinii STE20 , a Gene Complementing the Mating and Pseudohyphal Growth Defects of ste20 Mutant Yeast

Abstract excerpt

Pneumocystis carinii causes severe pneumonia in immunocompromised hosts. The binding of P. carinii to alveolar epithelial cells and extracellular matrix constituents such as fibronectin and vitronectin is a central feature of infection, which initiates proliferation of the organism. Herein, we demonstrate that P. carinii binding to lung cells specifically alters the gene expression of the organism, regulating...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Antifungal resistance and susceptibility
• Share to Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis