Article
Pneumocystis carinii uses a functional cdc13 B-type cyclin complex during its life cycle.
American journal of respiratory cell and molecular biology - 1 Jun 2000
Kottom T J, Thomas C F, Mubarak K K, Leof E B, Limper A H
Abstract excerpt
Pneumocystis carinii causes severe pneumonia in immunocompromised patients. Recent studies indicate that P. carinii uses a Cdc2 cyclin-dependent kinase to control its proliferation. To further study the regulation of the life cycle of P. carinii, we characterized the P. carinii B-type cyclin termed Cdc13, whose binding to Cdc2 is necessary for kinase activity. Antibodies to B-type cyclins (Cdc13) specifically...
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