Article
An assessment of ADAMs in bone cells: absence of TACE activity prevents osteoclast recruitment and the formation of the marrow cavity in developing long bones.
FEBS letters - 23 Oct 2003
Boissy Patrice, Lenhard Thomas R, Kirkegaard Tove, Peschon Jacques J, Black Roy A, Delaissé Jean-Marie, del Carmen Ovejero Maria
Abstract excerpt
ADAMs (A Disintegrin And Metalloprotease domain) are metalloprotease-disintegrin proteins that have been implicated in cell adhesion, protein ectodomain shedding, matrix protein degradation and cell fusion. Since such events are critical for bone resorption and osteoclast recruitment, we investigated whether they require ADAMs. We report here which ADAMs we have identified in bone cells, as well as our analysis...
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