Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Developmental differences in the immortalization of lung fibroblasts by telomerase

20 Aug 2003

Abstract excerpt

The role of ambient (21%) and physiological oxygen (2-5%) in the immortalization of fetal vs. adult human lung fibroblasts was examined. Growth in low oxygen and antioxidants extended the lifespan of both fetal and adult strains. As the ectopic expression of telomerase could immortalize adult lung fibroblasts cultured in ambient oxygen, the lifespan-shortening effects of 21% oxygen must have been largely limited...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Infant Nutrition and Health
Share to Neonatal Respiratory Health Research
Share to Telomeres, Telomerase, and Senescence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 14570231
DOI: 10.1046/j.1474-9728.2003.00057.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 10 closest

Developmental differences in the immortalization of lung fibroblasts by telomerasePMID 14570231Read ↗

Telomere dysfunction causes alveolar stem cell failureSemantic proximity Read ↗

Low atmospheric oxygen avoids maturation, senescence and cell death of murine mesencephalic neural precursorsSemantic proximity Read ↗

Oxygen accelerates the accumulation of mutations during the senescence and immortalization of murine cells in culture.Semantic proximity Read ↗

Stimuli-specific senescence of primary human lung fibroblasts modulates alveolar stem cell functionSemantic proximity Read ↗

Mitochondrial Reactive Oxygen Species Trigger Hypoxia-Inducible Factor-Dependent Extension of the Replicative Life Span during HypoxiaSemantic proximity Read ↗

Effects of Oxidative Damage and Telomerase Activity on Human Articular Cartilage Chondrocyte SenescenceSemantic proximity Read ↗

Mild hyperoxia shortens telomeres and inhibits proliferation of fibroblasts: a model for senescence?Semantic proximity Read ↗

Developmental and tissue-specific regulation of mouse telomerase and telomere length.Semantic proximity Read ↗

Developmental regulation of telomerase activity in human fetal tissues during gestationSemantic proximity Read ↗

Wild-derived inbred mouse strains have short telomeresSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.