Article
Identification of novel targets in scleroderma: update on population studies, cDNA arrays, SNP analysis, and mutations.
Current opinion in rheumatology - 1 Nov 2003
Ahmed S Sohail, Tan Filemon K
Abstract excerpt
PURPOSE OF REVIEW: Systemic sclerosis, or scleroderma, is an uncommon autoimmune connective tissue disease that results in systemic fibrosis. Its etiologic basis remains unclear. The pathogenesis of systemic sclerosis involves a proliferative and obliterative vasculopathy resulting from endothelial cell dysfunction, extensive fibrosis secondary to fibroblast activation, and autoimmunity as demonstrated by the...
Topics
- Autoantibodies
- DNA Mutational Analysis
- Female
- Genetic Predisposition to Disease
- Genetic Testing
- Genetics, Population
- Genome
- Genotype
- Humans
- Male
- Oligonucleotide Array Sequence Analysis