Article
Transcriptional expression of survivin and its splice variants in brain tumors in humans.
Journal of neurosurgery - 1 Oct 2003
Yamada Yoshitaka, Kuroiwa Toshihiko, Nakagawa Toshimasa, Kajimoto Yoshinaga, Dohi Takehiko, Azuma Haruhito, Tsuji Motomu, Kami Kazuhiro, Miyatake Shin-Ichi
Abstract excerpt
OBJECT: Survivin, one of the apoptosis inhibitor proteins, has been detected in most cancers in humans. In addition, two splice variants (survivin-2B and survivin-deltaEx3) have been identified. The authors investigated the transcription levels of survivin messenger (m)RNA and its splice variants in nine tumor cell lines, including gliomas, and in 25 brain tumor samples, by performing quantitative reverse...
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