Article
Uroguanylin knockout mice have increased blood pressure and impaired natriuretic response to enteral NaCl load.
The Journal of clinical investigation - 1 Oct 2003
Lorenz John N, Nieman Michelle, Sabo Jenine, Sanford L Philip, Hawkins Jennifer A, Elitsur Noeet, Gawenis Lara R, Clarke Lane L, Cohen Mitchell B
Abstract excerpt
Guanylin and uroguanylin, peptides synthesized in the intestine and kidney, have been postulated to have both paracrine and endocrine functions, forming a potential enteric-renal link to coordinate salt ingestion with natriuresis. To explore the in vivo role of uroguanylin in the regulation of sodium excretion, we created gene-targeted mice in which uroguanylin gene expression had been ablated. Northern and...
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