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Article

Control of telomere length by the human telomeric protein TRF1.

Nature - 20 Feb 1997

van Steensel B, de Lange T

Abstract excerpt

Human telomeres, the nucleoprotein complexes at chromosome ends, consist of tandem arrays of TTAGGG repeats bound to specific proteins. In normal human cells, telomeres shorten with successive cell divisions, probably due to the terminal sequence loss that accompanies DNA replication. In tumours and immortalized cells, this decline is halted through the activation of telomerase, a reverse transcriptase that...

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PMID: 9034193
DOI: 10.1038/385740a0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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Related research

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Research trail→

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Control of telomere length by the human telomeric protein TRF1.PMID 9034193Read ↗

Control of Human Telomere Length by TRF1 and TRF2Semantic proximity Read ↗

TELOMERE LENGTH REGULATIONSemantic proximity Read ↗

Importance of TRF1 for functional telomere structure.Semantic proximity Read ↗

A Human Telomeric ProteinSemantic proximity Read ↗

Inhibition of telomerase limits the growth of human cancer cells.Semantic proximity Read ↗

Regulation of the Human Telomerase Gene TERT by Telomere Position Effect—Over Long Distances (TPE-OLD): Implications for Aging and CancerSemantic proximity Read ↗

Regulation of Telomerase by Telomeric ProteinsSemantic proximity Read ↗

E2F-1 represses transcription of the human telomerase reverse transcriptase gene.Semantic proximity Read ↗

TRF2 overexpression diminishes repair of telomeric single-strand breaks and accelerates telomere shortening in human fibroblastsSemantic proximity Read ↗

Multiple cancer pathways regulate telomere protectionSemantic proximity Read ↗

Telomerase Inhibitor PinX1 Provides a Link between TRF1 and Telomerase to Prevent Telomere ElongationSemantic proximity Read ↗

A role for the Rb family of proteins in controlling telomere length.Semantic proximity Read ↗

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