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Article

Latent gene sequencing reveals familial relationships among Chinese Epstein-Barr virus strains and evidence for positive selection of A11 epitope changes.

Journal of virology - 1 Nov 2003

Midgley R S, Bell A I, McGeoch D J, Rickinson A B

Abstract excerpt

Epstein-Barr virus (EBV) strains from the highly HLA-A11-positive Chinese population are predominantly type 1 and show a variety of sequence changes (relative to the contemporary Caucasian prototype strain B95.8) in the nuclear antigen EBNA3B sequences encoding two immunodominant HLA-A11 epitopes, here called IVT and AVF. This has been interpreted by some as evidence of immune selection and by others as random...

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Identifiers

PMID: 14557637
DOI: 10.1128/jvi.77.21.11517-11530.2003
PMCID: PMC229270

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