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Article

Evolutionary dynamics of genetic variation in Epstein-Barr virus isolates of diverse geographical origins: evidence for immune pressure-independent genetic drift.

Journal of virology - 1 Nov 1997

Khanna R, Slade R W, Poulsen L, Moss D J, Burrows S R, Nicholls J, Burrows J M

Abstract excerpt

The question whether immune pressure exerted by cytotoxic T lymphocytes (CTLs) can influence the long-term evolution of genetically stable viruses such as Epstein-Barr virus (EBV) has generated considerable scientific interest, primarily due to its important implications for the overall biology of the virus. While arguing for a role of CTLs in the evolution of viruses, it is important to differentiate between...

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Identifiers

PMID: 9343187
DOI: 10.1128/JVI.71.11.8340-8346.1997
PMCID: PMC192293

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