Article
T cell responses and virus evolution: loss of HLA A11-restricted CTL epitopes in Epstein-Barr virus isolates from highly A11-positive populations by selective mutation of anchor residues.
The Journal of experimental medicine - 1 Apr 1994
de Campos-Lima P O, Levitsky V, Brooks J, Lee S P, Hu L F, Rickinson A B, Masucci M G
Abstract excerpt
Epstein-Barr virus (EBV) is a B lymphotropic herpesvirus of humans that elicits strong HLA class I-restricted cytotoxic T lymphocyte (CTL) responses. An influence of such responses on virus evolution was first suggested by our finding that EBV isolates from the highly HLA A11-positive Papua New Guinea (PNG) population carried a lys-thr mutation at residue 424 of the nuclear antigen EBV-encoded nuclear antigen...
Topics
- Amino Acid Sequence
- Base Sequence
- Biological Evolution
- Burkitt Lymphoma
- China
- DNA, Viral
- Epitopes
- Ethnicity
- HLA-A Antigens
- HLA-A11 Antigen