Article
Functional studies of the Ssk1p response regulator protein of Candida albicans as determined by phenotypic analysis of receiver domain point mutants.
Molecular microbiology - 1 Nov 2006
Menon Veena, Li Dongmei, Chauhan Neeraj, Rajnarayanan Rajendram, Dubrovska Alla, West Ann H, Calderone Richard
Abstract excerpt
The Candida albicans response regulator protein Ssk1p regulates oxidant adaptation through the MAPK HOG1 pathway. Deletion mutants lacking SSK1 are oxidant sensitive in vitro and are killed more than wild-type (WT) cells by human neutrophils. Furthermore, the mutants are avirulent in an invasive...
Topics
- Amino Acid Sequence
- Candida albicans
- Fungal Proteins
- MAP Kinase Signaling System
- Mitogen-Activated Protein Kinases
- Molecular Sequence Data
- Morphogenesis
- Oxidative Stress
- Phenotype
- Phosphorylation
- Point Mutation
- Protein Structure, Tertiary
- Protein Transport
- Sequence Alignment