Article
Regulation of the Candida albicans cell wall damage response by transcription factor Sko1 and PAS kinase Psk1.
Molecular biology of the cell - 1 Jul 2008
Rauceo Jason M, Blankenship Jill R, Fanning Saranna, Hamaker Jessica J, Deneault Jean-Sebastien, Smith Frank J, Nantel Andre, Mitchell Aaron P
Abstract excerpt
The environmental niche of each fungus places distinct functional demands on the cell wall. Hence cell wall regulatory pathways may be highly divergent. We have pursued this hypothesis through analysis of Candida albicans transcription factor mutants that are hypersensitive to caspofungin, an inhibitor of beta-1,3-glucan synthase. We report here that mutations in SKO1 cause this phenotype. C. albicans Sko1...
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