Article
MICA, HLA-B haplotypic variation in five population groups of sub-Saharan African ancestry.
Genes and immunity - 1 Oct 2003
Tian W, Boggs D A, Uko G, Essiet A, Inyama M, Banjoko B, Adewole T, Ding W-Z, Mohseni M, Fritz R, Chen D-F, Palmer L J, Fraser P A
Abstract excerpt
The human major histocompatibility complex (MHC) class I chain-related gene A (MICA), located 46 kb centromeric to HLA-B, encodes a stress-inducible protein, which is a ligand for the NKG2D receptor. In addition to its primary role in immune surveillance, data suggest that MICA is involved in the immune response to transplants and in susceptibility to some diseases. In this study, 152 subjects from the Yoruba...
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