Article
Protein 4.2 is critical to CD47-membrane skeleton attachment in human red cells.
Blood - 1 Feb 2004
Dahl Kris Noel, Parthasarathy Ranganath, Westhoff Connie M, Layton D Mark, Discher Dennis E
Abstract excerpt
The reduction in expression of the integral membrane protein CD47 in human red blood cells (RBCs) deficient in protein 4.2 suggests that protein 4.2 may mediate a linkage of CD47 to the membrane skeleton. We compared the fractions of membrane skeleton-attached CD47, Rh-associated glycoprotein (RhAG), Rh, and band 3 in normal and protein 4.2-deficient cells using fluorescence-imaged microdeformation. We found that...
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