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Article

Common genetic variation in a basal promoter element alters DDAH2 expression in endothelial cells.

Biochemical and biophysical research communications - 24 Oct 2003

Jones L C, Tran C T L, Leiper J M, Hingorani A D, Vallance P

Abstract excerpt

Synthesis of the vasodilator nitric oxide (NO) can be inhibited by the endogenous methylarginines L-NMMA and ADMA. ADMA is elevated in a number of cardiovascular disorders in which NO availability is reduced. Elimination of ADMA from the body occurs primarily by enzymatic breakdown through the action of DDAH, of which two isoforms exist, DDAH1 and DDAH2. In this study we have identified a core promoter region of...

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Source

Identifiers

PMID: 14550280
DOI: 10.1016/j.bbrc.2003.09.097

Genes

DDAH2
DDAH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Common genetic variation in a basal promoter element alters DDAH2 expression in endothelial cells.PMID 14550280Read ↗

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