Inhibition of HIV-1 replication in cultured cells with antisense oligonucleotides encapsulated in immunoliposomes.

doi:10.1089/ard.1993.3.323

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Article

Inhibition of HIV-1 replication in cultured cells with antisense oligonucleotides encapsulated in immunoliposomes.

Antisense research and development - 1 Jan 1993

Zelphati O, Zon G, Leserman L

Abstract excerpt

Antisense oligonucleotides inhibit HIV replication in vitro, but their activity is limited by their sensitivity to nucleases and low cellular uptake. To see whether these problems could be circumvented, we compared effects of HIV-1 rev and tat gene-specific antisense phosphodiester or phosphorothioate oligonucleotides, either free in solution or encapsulated in antibody-targeted liposomes (immunoliposomes), on...

Topics

Animals
Antibody Specificity
Base Sequence
Cell Line
Drug Carriers
Enzyme-Linked Immunosorbent Assay
Genes, rev
Genes, tat
HIV-1
Histocompatibility Antigens Class I
Liposomes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Molecular Sequence Data

Oligonucleotides, Antisense

Phenotype

T-Lymphocytes

Thionucleotides

Virus Replication

Source

Open in PubMed

Identifiers

PMID: 8155974
DOI: 10.1089/ard.1993.3.323

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8155974-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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