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Article

Structural basis for histone and phosphohistone binding by the GCN5 histone acetyltransferase.

Molecular cell - 1 Aug 2003

Clements Adrienne, Poux Arienne N, Lo Wan-Sheng, Pillus Lorraine, Berger Shelley L, Marmorstein Ronen

Abstract excerpt

Distinct posttranslational modifications on histones occur in specific patterns to mediate certain chromosomal events. For example, on histone H3, phosphorylation at Ser10 can enhance GCN5-mediated Lys14 acetylation to promote transcription. To gain insight into the mechanism underlying this synergism, we determined the structure of Tetrahymena GCN5 (tGCN5) and coenzyme A (CoA) bound to unmodified and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 14536085
DOI: 10.1016/s1097-2765(03)00288-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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