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Article

Expression of the tumor suppressor gene PTEN is not altered in the progression of ovarian carcinomas and does not correlate with p27Kip1 expression.

Oncology reports - 1 Jan 2000

Schöndorf Thomas, Hoopmann Markus, Eversheim Barbara, Valter Markus M, Becker Martina, Wappenschmidt Barbara, Göhring Uwe-Jochen, Kübler Tanja, Schmutzler Rita K, Schäfer Robert

Abstract excerpt

This study was designed to investigate the role of PTEN in the progression of ovarian cancer. We performed mutation analysis and determined PTEN gene expression in tissue from both primary and relapsed cancers and in the corresponding occult metastases. Furthermore, p27Kip1 staining was conducted...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 14534684

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-14534684-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

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Expression of the tumor suppressor gene PTEN is not altered in the progression of ovarian carcinomas and does not correlate with p27Kip1 expression.PMID 14534684Read ↗

Frequent loss of PTEN expression is linked to elevated phosphorylated Akt levels, but not associated with p27 and cyclin D1 expression, in primary epithelial ovarian carcinomas.Semantic proximity Read ↗

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Mutation of the PTEN tumor suppressor gene is not a feature of ovarian cancers.Semantic proximity Read ↗

PTEN expression is consistent in colorectal cancer primaries and metastases and associates with patient survival.Semantic proximity Read ↗

Analysis of genetic and epigenetic alterations of the PTEN gene in gastric cancer.Semantic proximity Read ↗

PTEN mutation, expression and LOH at its locus in ovarian carcinomas. Relation to TP53, K-RAS and BRCA1 mutations.Semantic proximity Read ↗

Loss of PTEN expression is an independent predictor of favourable survival in endometrial carcinomasSemantic proximity Read ↗

PTEN induces G(1) cell cycle arrest and decreases cyclin D3 levels in endometrial carcinoma cells.Semantic proximity Read ↗

Novel mutations of the suppressor gene PTEN in colorectal carcinomas stratified by microsatellite instability- and TP53 mutation- status.Semantic proximity Read ↗

The role of PTEN and its signalling pathways, including AKT, in breast cancer; an assessment of relationships with other prognostic factors and with outcomeSemantic proximity Read ↗

Effects of mutation and expression of PTEN gene mRNA on tumorigenesis and progression of epithelial ovarian cancer.Semantic proximity Read ↗

Heterogeneous lack of expression of the tumour suppressor PTEN protein in human neoplastic tissuesSemantic proximity Read ↗

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