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Article

ApoE4 is more efficient than E3 in brain access by herpes simplex virus type 1

1 Oct 2003

Abstract excerpt

Apolipoprotein E (ApoE) plays a relevant role in herpes simplex type 1 (HSV-1) infection of the CNS; after infection by the hematogenous route, the viral neuroinvasiveness directly depends on the APOE gene dose. To analyze the effect of ApoE isoforms on the HSV-1 infectivity to the brain, we have used a model of hematogenous infection of mice humanized for the ApoE3 or the ApoE4 alleles, and we have analyzed the...

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PMID: 14534428
DOI: 10.1097/00001756-200310060-00013

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