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Article

PI3 kinase enhancer-Homer complex couples mGluRI to PI3 kinase, preventing neuronal apoptosis.

Nature neuroscience - 1 Nov 2003

Rong Rong, Ahn Jee-Yin, Huang Honglian, Nagata Eiichiro, Kalman Daniel, Kapp Judith A, Tu Jiancheng, Worley Paul F, Snyder Solomon H, Ye Keqiang

Abstract excerpt

Phosphoinositide 3 kinase enhancer (PIKE) is a recently identified nuclear GTPase that activates nuclear phosphoinositide 3-kinase (PI3 kinase). We have identified, cloned and characterized a new form of PIKE, designated PIKE-L, which, unlike the nuclear PIKE-S, localizes to both the cytoplasm an...

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PMID: 14528310
DOI: 10.1038/nn1134

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-14528310-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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