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Article

Nuclear localization of the G protein beta 5/R7-regulator of G protein signaling protein complex is dependent on R7 binding protein.

Journal of neurochemistry - 1 Jun 2010

Panicker Leelamma M, Zhang Jian-Hua, Posokhova Ekaterina, Gastinger Matthew J, Martemyanov Kirill A, Simonds William F

Abstract excerpt

The neuronally expressed G beta(5) subunit is the most structurally divergent among heterotrimeric G beta isoforms and unique in its ability to heterodimerize with the R7 subfamily of regulator of G protein signaling (RGS) proteins. The complex between G beta(5) and R7-type RGS proteins targets the cell nucleus by an unknown mechanism. Although the nuclear targeting of the G beta(5)/R7-RGS complex is proposed to...

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Identifiers

PMID: 20100282
DOI: 10.1111/j.1471-4159.2010.06616.x
PMCID: PMC2890294

Genes

RGS7

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