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Article

Single-cell analysis of covalently closed circular DNA copy numbers in a hepadnavirus-infected liver

3 Oct 2003

Abstract excerpt

Hepatitis B virus (hepadnavirus) infections are maintained by the presence of a small and regulated number of episomal viral genomes [covalently closed circular DNA (cccDNA)] in the nuclei of infected cells. Although a number of studies have measured the mean copy number of cccDNA molecules in hepadnaviral-infected cells, the distribution of individual copy numbers have not been reported. Using a PCR-based assay,...

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PMID: 14528003
DOI: 10.1073/pnas.2033898100

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