Article
Functional involvement of cathepsin W in the cytotoxic activity of NK-92 cells.
FEBS letters - 25 Sept 2003
Wex Thomas, Wex Heike, Hartig Roland, Wilhelmsen Skadi, Malfertheiner Peter
Abstract excerpt
Human cathepsin W (lymphopain) is a papain-like cysteine protease of unknown function that is specifically expressed in natural killer (NK) cells and to a lesser extent in cytotoxic T cells (CTL). In order to analyze the functional importance of cathepsin W for the cytotoxic process, we investigated NK-92 cells that have an NK cell-like phenotype and express cathepsin W. NK-92 cells possess strong cytotoxic...
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