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Article

Essential role of E2-25K/Hip-2 in mediating amyloid-beta neurotoxicity.

Molecular cell - 1 Sept 2003

Song Sungmin, Kim So-Young, Hong Yeon-Mi, Jo Dong-Gyu, Lee Joo-Yong, Shim Sang Mi, Chung Chul-Woong, Seo Soo Jung, Yoo Yung Joon, Koh Jae-Young, Lee Min Chul, Yates Allan J, Ichijo Hidenori, Jung Yong-Keun

Abstract excerpt

The ubiquitin/proteasome system has been proposed to play an important role in Alzheimer's disease (AD) pathogenesis. However, the critical factor(s) modulating both amyloid-beta peptide (Abeta) neurotoxicity and ubiquitin/proteasome system in AD are not known. We report the isolation of an unusu...

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Identifiers

PMID: 14527403
DOI: 10.1016/j.molcel.2003.08.005

Genes

UBB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-14527403-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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