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Identification of a cancer stem cell in human brain tumors.

Cancer research - 15 Sept 2003

Singh Sheila K, Clarke Ian D, Terasaki Mizuhiko, Bonn Victoria E, Hawkins Cynthia, Squire Jeremy, Dirks Peter B

Abstract excerpt

Most current research on human brain tumors is focused on the molecular and cellular analysis of the bulk tumor mass. However, there is overwhelming evidence in some malignancies that the tumor clone is heterogeneous with respect to proliferation and differentiation. In human leukemia, the tumor clone is organized as a hierarchy that originates from rare leukemic stem cells that possess extensive proliferative...

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PMID: 14522905

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