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Cancer Susceptibility Models in Protease-Deficient Mice.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2018

Folgueras Alicia R, Freitas-Rodríguez Sandra, Español Yaiza, Velasco Gloria

Abstract excerpt

For decades, proteases have been associated with cancer progression due to the ability of some members of this large group of enzymes to degrade tumor cell surroundings, thereby facilitating cancer invasion and dissemination. However, the generation of mouse models deficient in proteases has revealed the existence of a great variety of functions among proteolytic enzymes in cancer biology, including important...

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PMID: 29318558
DOI: 10.1007/978-1-4939-7595-2_21

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