Article
Small bristles, the Drosophila ortholog of NXF-1, is essential for mRNA export throughout development.
RNA (New York, N.Y.) - 1 Dec 2001
Wilkie G S, Zimyanin V, Kirby R, Korey C, Francis-Lang H, Van Vactor D, Davis I
Abstract excerpt
We identified a temperature-sensitive allele of small bristles (sbr), the Drosophila ortholog of human TAP/NXF-1 and yeast Mex67, in a screen for mutants defective in mRNA export. We show that sbr is essential for the nuclear export of all mRNAs tested in a wide range of tissues and times in development. High resolution and sensitive in situ hybridization detect the rapid accumulation of individual mRNA species...
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