Article
Human oligodendrocyte precursor cells in vitro: phenotypic analysis and differential response to growth factors.
Glia - 1 Nov 2003
Wilson Heather C, Onischke Claus, Raine Cedric S
Abstract excerpt
Following experimental demyelination in rodents, oligodendrocyte precursor cells (OPCs) proliferate and differentiate into myelin-producing oligodendrocytes which effect robust remyelination. In contrast, remyelination in multiple sclerosis, the major human demyelinating disease, is generally limited and transient. Rodent OPCs have been well characterized in vitro and their response to growth factors documented....
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