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Article

Role of the endothelin-1 gene locus for renal impairment in the general nondiabetic population.

Journal of the American Society of Nephrology : JASN - 1 Oct 2003

Pinto-Sietsma Sara-Joan, Herrmann Stefan-Martin, Schmidt-Petersen Klaus, Niu Tianhua, Hillege Hans L, Janssen Wilbert M T, de Zeeuw Dick, de Jong Paul, Kreutz Reinhold

Abstract excerpt

A decreased GFR in the range of mild renal insufficiency and an increased urinary albumin excretion (UAE) rate in the range of microalbuminuria are important cardiovascular risk factors. Endothelin-1 (ET-1) has been suggested to be a major disease promoting factor in renal disease. The role of th...

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Source

Identifiers

PMID: 14514737
DOI: 10.1097/01.asn.0000089827.03201.8e

Genes

EDN1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-14514737-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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