Article
Association between a specific Pneumocystis jiroveci dihydropteroate synthase mutation and failure of pyrimethamine/sulfadoxine prophylaxis in human immunodeficiency virus-positive and -negative patients.
The Journal of infectious diseases - 1 Oct 2003
Nahimana Aimable, Rabodonirina Meja, Zanetti Giorgio, Meneau Isabelle, Francioli Patrick, Bille Jacques, Hauser Philippe M
Abstract excerpt
To investigate the possible association between different prophylactic sulfa drugs and the genotype of the Pneumocystis jiroveci dihydropteroate synthase (DHPS) gene, we examined DHPS polymorphisms in clinical specimens from 158 immunosuppressed patients (38 HIV-negative and 120 HIV-positive), us...
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