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Interhuman Transmission as a Potential Key Parameter for Geographical Variation in the Prevalence ofPneumocystis jiroveciiDihydropteroate Synthase Mutations

6 Jul 2010

Abstract excerpt

BACKGROUND: Pneumocystis jirovecii dihydropteroate synthase (DHPS) mutations are associated with failure of prophylaxis with sulfa drugs. This retrospective study sought to better understand the geographical variation in the prevalence of these mutations. METHODS: DHPS polymorphisms in 394 clinical specimens from immunosuppressed patients who received a diagnosis of P. jirovecii pneumonia and who were...

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PMID: 20604718
DOI: 10.1086/655145

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