Article
Therapeutic strategies for Alzheimer disease: focus on neuronal reactivation of metabolically impaired neurons.
Alzheimer disease and associated disorders - 1 Jan 2000
Swaab D F, Dubelaar E J G, Scherder E J A, van Someren E J W, Verwer R W H
Abstract excerpt
Based on several lines of evidence, it has been hypothesized that decreased neuronal metabolic rate may precede cognitive impairment, contributing to neuronal atrophy as well as reduced neuronal function in Alzheimer disease (AD). Additionally, studies have shown that stimulation of neurons through different mechanisms may protect those cells from the deleterious effects of aging and AD, a phenomenon we...
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