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Article

Altered expression of MLH1, MSH2, and MSH6 in predisposition to hereditary nonpolyposis colorectal cancer.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 1 Oct 2003

Renkonen Elise, Zhang Yange, Lohi Hannes, Salovaara Reijo, Abdel-Rahman Wael M, Nilbert Mef, Aittomaki Kristiina, Jarvinen Heikki J, Mecklin Jukka-Pekka, Lindblom Annika, Peltomaki Paivi

Abstract excerpt

PURPOSE: A considerable fraction (30% to 70%) of families with verified or putative hereditary nonpolyposis colorectal cancer fails to show mutations in DNA mismatch repair (MMR) genes. Our purpose was to address the genetic etiology of such families. MATERIALS AND METHODS: We scrutinized a popul...

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Share to Adaptor Proteins, Signal Transducing
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Colorectal Neoplasms, Hereditary Nonpolyposis

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Source

Identifiers

PMID: 14512394
DOI: 10.1200/JCO.2003.03.181

Genes

MLH1
MSH2
MSH6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-14512394-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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