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Article

MLH1 germline epimutations as a factor in hereditary nonpolyposis colorectal cancer.

Gastroenterology - 1 Nov 2005

Hitchins Megan, Williams Rachel, Cheong Kayfong, Halani Nimita, Lin Vita A P, Packham Deborah, Ku Sue, Buckle Andrew, Hawkins Nicholas, Burn John, Gallinger Steven, Goldblatt Jack, Kirk Judy, Tomlinson Ian, Scott Rodney, Spigelman Allan, Suter Catherine, Martin David, Suthers Graeme, Ward Robyn

Abstract excerpt

BACKGROUND & AIMS: Hereditary nonpolyposis colorectal cancer (HNPCC) is caused by heterozygous germline sequence mutations of DNA mismatch repair genes, most frequently MLH1 or MSH2. A novel molecular mechanism for HNPCC has recently been suggested by the finding of individuals with soma-wide monoallelic hypermethylation of the MLH1 gene promoter. In this study, we determined the frequency and role of germline...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Colorectal Neoplasms, Hereditary Nonpolyposis

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Share to Gene Expression Regulation, Neoplastic

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Source

Identifiers

PMID: 16285940
DOI: 10.1053/j.gastro.2005.09.003

Genes

MLH1
MSH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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MLH1 germline epimutations as a factor in hereditary nonpolyposis colorectal cancer.PMID 16285940Read ↗

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