Article
The (-174) G/C polymorphism in the interleukin-6 gene is associated with the severity of acute cerebrovascular events.
Thrombosis research - 1 Jun 2003
Greisenegger Stefan, Endler Georg, Haering Daniela, Schillinger Martin, Lang Wilfried, Lalouschek Wolfgang, Mannhalter Christine
Abstract excerpt
BACKGROUND AND PURPOSE: Elevated plasma levels of interleukin-6 (IL-6) are associated with an increased risk and worse outcome of acute vascular events. A common G/C promoter polymorphism at nt (-174) of the IL-6 gene has been shown to affect basal IL-6 levels. Consequently, the IL-6 genotype may be associated with risk and outcome of ischemic stroke (IS). We investigated the statistical association between this...
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