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Article

A -174G/C polymorphism of the interleukin-6 gene in patients with lacunar infarction.

Neuroscience letters - 10 May 2002

Revilla Marián, Obach Víctor, Cervera Alvaro, Dávalos Antonio, Castillo José, Chamorro Angel

Abstract excerpt

Interleukin-6 (IL-6) is a pleiotropic cytokine that plays a central role in the pathogenesis of stroke. A base pair substitution -174G/C in the promoter region of the IL-6 gene regulates IL-6 gene expression. We compared the prevalence of this polymorphism in patients with lacunar stroke and in an age- and sex-matched cohort of asymptomatic controls. Eighty-two patients with lacunar stroke and 82 asymptomatic...

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Identifiers

PMID: 11983287
DOI: 10.1016/s0304-3940(02)00169-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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A -174G/C polymorphism of the interleukin-6 gene in patients with lacunar infarction.PMID 11983287Read ↗

Interleukin-6 174G/C polymorphism and ischemic stroke: a systematic review.Semantic proximity Read ↗

The -174G/C polymorphism of the interleukin 6 gene is a hallmark of lacunar stroke and not other ischemic stroke phenotypes.Semantic proximity Read ↗

Interleukin-6 gene -174 G/C promoter polymorphism predicts severity and outcome in acute ischemic stroke patients from north India.Semantic proximity Read ↗

Interleukin 6 promoter 174 G/C polymorphisms in acute ischemic stroke: G allele is protective but not associated with IL-6 levels or stroke outcome.Semantic proximity Read ↗

The association of functional polymorphisms of IL-6 gene promoter with ischemic stroke: analysis in two Chinese populations.Semantic proximity Read ↗

Association between the interleukin-6-174 G/C polymorphism and risk of ischemic stroke: a meta-analysis.Semantic proximity Read ↗

Association between interleukin-6 (G174C and C572G) promoter gene polymorphisms and risk of ischemic stroke in North Indian population: a case-control study.Semantic proximity Read ↗

The (-174) G/C polymorphism in the interleukin-6 gene is associated with the severity of acute cerebrovascular events.Semantic proximity Read ↗

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Association between Interleukin-6 (G174C and G572C) promoter gene polymorphisms and risk of ischaemic stroke: A meta-analysisSemantic proximity Read ↗

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