Article
Cellular and serological responses in resistant and susceptible mice exposed to repeated infection with Heligmosomoides polygyrus bakeri.
Parasite immunology - 1 Jun 2003
Behnke Jerzy M, Lowe Anna, Clifford Simon, Wakelin Derek
Abstract excerpt
An experiment was carried out to compare the parasitological and immunological responses of SWR and CBA mice to trickle (repeated) infection with Heligmosomoides polygyrus. Male mice were given 125 L3 once per week and were killed in groups, together with naïve control mice, weekly until week 8. Worm burdens accumulated in CBA, stabilizing in week 5 in excess of 400 worms and remaining high until week 8. In...
Topics
- Animals
- Antibodies, Helminth
- Cell Count
- Chemokine CCL2
- Chymases
- Feces
- Genetic Predisposition to Disease
- Goblet Cells
- Immunoglobulin Isotypes
- Intestinal Mucosa
- Male
- Mast Cells
- Mice
- Mice, Inbred CBA
- Nematospiroides dubius