Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

In vivo somatic microsatellite mutations identified in non-malignant human tissue.

Human genetics - 1 Dec 2003

Mann Kathy, Donaghue Celia, Ogilvie Caroline Mackie

Abstract excerpt

Microsatellite instability (MSI) has been described in cancer cells and in vitro cell lines, and meiotic changes in repeat length have also been documented. We report the novel observation of somatic microsatellite mutation (SMM) in normal human somatic cells in vivo, detected while genotyping 5767 prenatal samples (4640 amniotic fluid samples and 1127 chorionic villus biopsies) as a diagnostic test for exclusion...

Topics

Alleles
Amniotic Fluid
Female
Genetic Markers
Heterozygote
Humans
Male
Microsatellite Repeats
Mutation
Parents
Pregnancy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 14505038
DOI: 10.1007/s00439-003-1032-3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

In vivo somatic microsatellite mutations identified in non-malignant human tissue.PMID 14505038Read ↗

Extensive somatic microsatellite mutations in normal human tissue.Semantic proximity Read ↗

Microsatellite instability in human cancer.Semantic proximity Read ↗

Microsatellite instability in inherited and sporadic neoplasms.Semantic proximity Read ↗

Defective Mismatch Repair, Microsatellite Mutation Bias, and Variability in Clinical Cancer PhenotypesSemantic proximity Read ↗

Somatic mutation processes at a human minisatellite.Semantic proximity Read ↗

Microsatellite alterations as clonal markers for the detection of human cancer.Semantic proximity Read ↗

Detection of mitochondrial DNA mutations in gestational trophoblastic disease.Semantic proximity Read ↗

Two modes of germline instability at human minisatellite MS1 (locus D1S7): complex rearrangements and paradoxical hyperdeletion.Semantic proximity Read ↗

Microsatellite instability markers in breast cancer: a review and study showing MSI was not detected at 'BAT 25' and 'BAT 26' microsatellite markers in early-onset breast cancer.Semantic proximity Read ↗

Mutation rate and specificity analysis of tetranucleotide microsatellite DNA alleles in somatic human cells.Semantic proximity Read ↗

Microsatellite instability is infrequent in sporadic adult gliomas.Semantic proximity Read ↗

The mutational spectrum of human autosomal tetranucleotide microsatellites.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.