Article
RNA inhibition of BMP-4 gene expression in postimplantation mouse embryos.
Genesis (New York, N.Y. : 2000) - 1 Sept 2003
Gratsch Theresa E, De Boer Lisa S, O'Shea K Sue
Abstract excerpt
Short, hairpin RNA (shRNA) directed against bone morphogenetic protein 4 (Bmp-4) was delivered to early postimplantation staged mouse embryos via tail vein injection of pregnant dams. As early as 24 h postinjection, embryos expressed a DsRed marker and later exhibited defects of neural fold elevation and closure and of cardiac morphogenesis. Immunohistochemical analysis of sectioned embryos indicated that Bmp-4...
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