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Article

P16(INK⁴a) overexpression is associated with CDKN2A mutation and worse prognosis in HPV-negative laryngeal squamous cell carcinomas.

Virchows Archiv : an international journal of pathology - 1 Apr 2015

Larque Ana B, Conde Laura, Hakim Sofia, Alos Llucia, Jares Pedro, Vilaseca Isabel, Cardesa Antonio, Nadal Alfons

Abstract excerpt

We studied the expression of p16(INK4a) in a series of HPV-negative laryngeal squamous cell carcinomas and assessed its association with prognosis. Forty-five patients with laryngeal carcinoma were included in the study. Clinicopathological features and prognosis were reviewed. p16(INK4a) protein expression was analysed through immunohistochemistry. We analysed messenger RNA (mRNA) in 25 cases through...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Squamous Cell Carcinoma of Head and Neck

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Identifiers

PMID: 25652585
DOI: 10.1007/s00428-015-1725-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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