Article
Different strains of Mycobacterium tuberculosis cause various spectrums of disease in the rabbit model of tuberculosis.
Infection and immunity - 1 Oct 2003
Manabe Yukari C, Dannenberg Arthur M, Tyagi Sandeep K, Hatem Christine L, Yoder Mark, Woolwine Samuel C, Zook Bernard C, Pitt M Louise M, Bishai William R
Abstract excerpt
The rabbit model of tuberculosis has been used historically to differentiate between Mycobacterium tuberculosis and Mycobacterium bovis based on their relative virulence in this animal host. M. tuberculosis infection in market rabbits is cleared over time, whereas infection with M. bovis results in chronic, progressive, cavitary disease leading to death. Because of the innate resistance of commercial rabbits to...
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