Article
Atg28, a novel coiled-coil protein involved in autophagic degradation of peroxisomes in the methylotrophic yeast Pichia pastoris.
Autophagy - 1 Jan 2000
Stasyk Oleh V, Stasyk Olena G, Mathewson Richard D, Farré Jean-Claude, Nazarko Volodymyr Y, Krasovska Olena S, Subramani Suresh, Cregg James M, Sibirny Andriy A
Abstract excerpt
In methylotrophic yeasts, peroxisomes are required for methanol utilization, but are dispensable for growth on most other carbon sources. Upon adaptation of cells grown on methanol to glucose or ethanol, redundant peroxisomes are selectively and quickly shipped to, and degraded in, vacuoles via a process termed pexophagy. We identified a novel gene named ATG28 (autophagy-related genes) involved in pexophagy in...
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