Article
The pas8 mutant of Pichia pastoris exhibits the peroxisomal protein import deficiencies of Zellweger syndrome cells--the PAS8 protein binds to the COOH-terminal tripeptide peroxisomal targeting signal, and is a member of the TPR protein family.
The Journal of cell biology - 1 May 1993
McCollum D, Monosov E, Subramani S
Abstract excerpt
We previously described the isolation of mutants of the yeast Pichia pastoris that are deficient in peroxisome assembly (pas mutants). We describe the characterization of one of these mutants, pas8, and the cloning of the PAS8 gene. The pas8 mutant is deficient for growth, but not for division or...
Topics
- Acetyl-CoA C-Acetyltransferase
- Amino Acid Sequence
- Base Sequence
- Biological Transport
- Cloning, Molecular
- DNA, Fungal
- Fungal Proteins
- Humans
- Luciferases
- Membrane Proteins
- Methanol
- Microbodies
- Microscopy, Immunoelectron
- Molecular Sequence Data