Article
Secretory pathway of beta/A4 amyloid protein precursor in familial Alzheimer's disease with Val717 to Ile mutation.
Neuroscience letters - 14 Sept 1992
Yanagisawa K, Ihara Y, Miyatake T
Abstract excerpt
To determine whether the secretory pathway of beta/A4 amyloid protein precursor (APP) was altered in familial Alzheimer's disease (FAD) with a mutation of Val717 to Ile, cerebrospinal fluid was studied by Western blotting. The ratio of the density of the bands labeled with the antibody against the amino-terminal part of beta/A4 protein to that with the antibody against amino-terminal part of beta/A4 protein to...
Topics
- Alzheimer Disease
- Amyloid beta-Protein Precursor
- Blotting, Western
- Cells, Cultured
- Humans
- Isoleucine
- Mutation
- Nervous System Diseases
- Valine