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Article

Recovery of cholinergic phenotype in the injured rat neostriatum: roles for endogenous and exogenous nerve growth factor.

Journal of neurochemistry - 1 Dec 1992

Altar C A, Armanini M, Dugich-Djordjevic M, Bennett G L, Williams R, Feinglass S, Anicetti V, Sinicropi D, Bakhit C

Abstract excerpt

Polyclonal antibodies against recombinant human nerve growth factor (rhNGF) potently inhibited PC12 neurite outgrowth, blocked high-affinity 125I-rhNGF binding but not its receptor, and cross-reacted with rat, mouse, and human nerve growth factor (NGF) but not with brain-derived neurotrophic factor, neurotrophin-3, ciliary neurotrophic factor, insulin-like growth factor, epidermal growth factor, or activin A....

Topics

Animals
Antibodies
Antibody Specificity
Astrocytes
Choline
Choline O-Acetyltransferase
Dose-Response Relationship, Drug
Enzyme-Linked Immunosorbent Assay
Glial Fibrillary Acidic Protein
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Immunohistochemistry

Iodine Radioisotopes

Male

Neostriatum

Nerve Growth Factors

Neurons

PC12 Cells

Phenotype

Source

Identifiers

PMID: 1431899
DOI: 10.1111/j.1471-4159.1992.tb10108.x

Genes

NGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1431899-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Recovery of cholinergic phenotype in the injured rat neostriatum: roles for endogenous and exogenous nerve growth factor.PMID 1431899Read ↗

Central infusions of brain-derived neurotrophic factor and neurotrophin-4/5, but not nerve growth factor and neurotrophin-3, prevent loss of the cholinergic phenotype in injured adult motor neurons.Semantic proximity Read ↗

Experimental neurotrophic factor therapy leads to cortical synaptic remodeling and compensates for behavioral deficits.Semantic proximity Read ↗

Maintaining the neuronal phenotype after injury in the adult CNS. Neurotrophic factors, axonal growth substrates, and gene therapy.Semantic proximity Read ↗

GDNF gene delivery to injured adult CNS motor neurons promotes axonal growth, expression of the trophic neuropeptide CGRP, and cellular protection.Semantic proximity Read ↗

Nerve growth factor and glial cell line-derived neurotrophic factor restore the cholinergic neuronal phenotype in organotypic brain slices of the basal nucleus of Meynert.Semantic proximity Read ↗

Distinct neurotrophic responses of axotomized motor neurons to BDNF and CNTF in adult rats.Semantic proximity Read ↗

The neurotrophins BDNF, NT-3 and NT-4/5, but not NGF, up-regulate the cholinergic phenotype of developing motor neurons.Semantic proximity Read ↗

Differential modulation of the cholinergic phenotype of the nucleus basalis magnocellularis neurons by applying NGF at the cell body or cortical terminal fields.Semantic proximity Read ↗

Injured primary sensory neurons switch phenotype for brain-derived neurotrophic factor in the rat.Semantic proximity Read ↗

Repeated Intravenous Administration of Human Neural Stem Cells Encoding Choline Acetyltransferase Gene Exhibits Anti-ageing Activities Displaying Enhanced Cognitive and Physical FunctionsSemantic proximity Read ↗

Further characterization of the effects of brain-derived neurotrophic factor and ciliary neurotrophic factor on axotomized neonatal and adult mammalian motor neurons.Semantic proximity Read ↗

PC12nnr5 cells expressing TrkA receptors undergo morphological but not cholinergic phenotypic differentiation in response to nerve growth factor.Semantic proximity Read ↗

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