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Article

Recovery of cholinergic phenotype in the injured rat neostriatum: roles for endogenous and exogenous nerve growth factor.

Journal of neurochemistry - 1 Dec 1992

Altar C A, Armanini M, Dugich-Djordjevic M, Bennett G L, Williams R, Feinglass S, Anicetti V, Sinicropi D, Bakhit C

Abstract excerpt

Polyclonal antibodies against recombinant human nerve growth factor (rhNGF) potently inhibited PC12 neurite outgrowth, blocked high-affinity 125I-rhNGF binding but not its receptor, and cross-reacted with rat, mouse, and human nerve growth factor (NGF) but not with brain-derived neurotrophic factor, neurotrophin-3, ciliary neurotrophic factor, insulin-like growth factor, epidermal growth factor, or activin A....

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Source

Identifiers

PMID: 1431899
DOI: 10.1111/j.1471-4159.1992.tb10108.x

Genes

NGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Recovery of cholinergic phenotype in the injured rat neostriatum: roles for endogenous and exogenous nerve growth factor.PMID 1431899Read ↗

Central infusions of brain-derived neurotrophic factor and neurotrophin-4/5, but not nerve growth factor and neurotrophin-3, prevent loss of the cholinergic phenotype in injured adult motor neurons.Semantic proximity Read ↗

Experimental neurotrophic factor therapy leads to cortical synaptic remodeling and compensates for behavioral deficits.Semantic proximity Read ↗

Maintaining the neuronal phenotype after injury in the adult CNS. Neurotrophic factors, axonal growth substrates, and gene therapy.Semantic proximity Read ↗

GDNF gene delivery to injured adult CNS motor neurons promotes axonal growth, expression of the trophic neuropeptide CGRP, and cellular protection.Semantic proximity Read ↗

Nerve growth factor and glial cell line-derived neurotrophic factor restore the cholinergic neuronal phenotype in organotypic brain slices of the basal nucleus of Meynert.Semantic proximity Read ↗

Distinct neurotrophic responses of axotomized motor neurons to BDNF and CNTF in adult rats.Semantic proximity Read ↗

The neurotrophins BDNF, NT-3 and NT-4/5, but not NGF, up-regulate the cholinergic phenotype of developing motor neurons.Semantic proximity Read ↗

Differential modulation of the cholinergic phenotype of the nucleus basalis magnocellularis neurons by applying NGF at the cell body or cortical terminal fields.Semantic proximity Read ↗

Injured primary sensory neurons switch phenotype for brain-derived neurotrophic factor in the rat.Semantic proximity Read ↗

Repeated Intravenous Administration of Human Neural Stem Cells Encoding Choline Acetyltransferase Gene Exhibits Anti-ageing Activities Displaying Enhanced Cognitive and Physical FunctionsSemantic proximity Read ↗

Further characterization of the effects of brain-derived neurotrophic factor and ciliary neurotrophic factor on axotomized neonatal and adult mammalian motor neurons.Semantic proximity Read ↗

PC12nnr5 cells expressing TrkA receptors undergo morphological but not cholinergic phenotypic differentiation in response to nerve growth factor.Semantic proximity Read ↗

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