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Article

orthodenticle activity is required for the development of medial structures in the larval and adult epidermis of Drosophila.

Development (Cambridge, England) - 1 Jul 1992

Wieschaus E, Perrimon N, Finkelstein R

Abstract excerpt

Lethal alleles of orthodenticle (= otd) cause abnormalities in the embryonic head that reflect an early role in anterior pattern formation. In addition, otd activity is required for the development of the larval and adult epidermis. Clonal analysis of both viable and lethal alleles shows that the adult requirement for otd is restricted to medial regions of certain discs. When otd activity is reduced or removed,...

Topics

Animals
Drosophila
Embryonic Induction
Genes
Morphogenesis
Mosaicism
Phenotype

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 1425355
DOI: 10.1242/dev.115.3.801

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1425355-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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orthodenticle activity is required for the development of medial structures in the larval and adult epidermis of Drosophila.PMID 1425355Read ↗

The orthodenticle gene encodes a novel homeo domain protein involved in the development of the Drosophila nervous system and ocellar visual structures.Semantic proximity Read ↗

Epidermal growth factor receptor signaling activates orthodenticle expression during Drosophila head development.Semantic proximity Read ↗

orthodenticle is required for photoreceptor cell development in the Drosophila eye.Semantic proximity Read ↗

Pattern formation in Drosophila head development: the role of the orthodenticle homeobox gene.Semantic proximity Read ↗

The orthodenticle gene is regulated by bicoid and torso and specifies Drosophila head development.Semantic proximity Read ↗

A targeted mouse Otx2 mutation leads to severe defects in gastrulation and formation of axial mesoderm and to deletion of rostral brain.Semantic proximity Read ↗

Apparent role of Tribolium orthodenticle in anteroposterior blastoderm patterning largely reflects novel functions in dorsoventral axis formation and cell survival.Semantic proximity Read ↗

Analysis of the Otd-dependent transcriptome supports the evolutionary conservation of CRX/OTX/OTD functions in flies and vertebrates.Semantic proximity Read ↗

Equivalence of the fly orthodenticle gene and the human OTX genes in embryonic brain development of Drosophila.Semantic proximity Read ↗

Pair-rule gene runt restricts orthodenticle expression to the presumptive head of the Drosophila embryo.Semantic proximity Read ↗

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oto is a homeotic locus with a role in anteroposterior development that is partially redundant with Lim1.Semantic proximity Read ↗

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