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Article

The genes orthodenticle and hunchback substitute for bicoid in the beetle Tribolium.

Nature - 10 Apr 2003

Schröder Reinhard

Abstract excerpt

In Drosophila, the morphogen Bicoid organizes anterior patterning in a concentration-dependent manner by activating the transcription of target genes such as orthodenticle (otd) and hunchback (hb), and by repressing the translation of caudal. Homologues of the bicoid gene have not been isolated in any organism apart from the higher Dipterans. In fact, head and thorax formation in other insects is poorly...

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PMID: 12687002
DOI: 10.1038/nature01536

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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The genes orthodenticle and hunchback substitute for bicoid in the beetle Tribolium.PMID 12687002Read ↗

The orthodenticle gene is regulated by bicoid and torso and specifies Drosophila head development.Semantic proximity Read ↗

Apparent role of Tribolium orthodenticle in anteroposterior blastoderm patterning largely reflects novel functions in dorsoventral axis formation and cell survival.Semantic proximity Read ↗

Candidate gene screen in the red flour beetle Tribolium reveals six3 as ancient regulator of anterior median head and central complex development.Semantic proximity Read ↗

A deficiency of the homeotic complex of the beetle Tribolium.Semantic proximity Read ↗

FGF signalling controls anterior extraembryonic and embryonic fate in the beetle Tribolium.Semantic proximity Read ↗

Neofunctionalization of embryonic head patterning genes facilitates the positioning of novel traits on the dorsal head of adult beetles.Semantic proximity Read ↗

Implications of the Tribolium Deformed mutant phenotype for the evolution of Hox gene function.Semantic proximity Read ↗

foxQ2 evolved a key role in anterior head and central brain patterning in protostomesSemantic proximity Read ↗

Characterization of the Tribolium Deformed ortholog and its ability to directly regulate Deformed target genes in the rescue of a Drosophila Deformed null mutant.Semantic proximity Read ↗

Embryonic patterning mutants of Tribolium castaneum.Semantic proximity Read ↗

Structure and function of the homeotic gene complex (HOM-C) in the beetle, Tribolium castaneum.Semantic proximity Read ↗

The Tribolium homeotic gene Abdominal is homologous to abdominal-A of the Drosophila bithorax complex.Semantic proximity Read ↗

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